1998-07-03 · Osteoadherin, a Cell-binding Keratan Sulfate Proteoglycan in Bone, Belongs to the Family of Leucine-rich Repeat Proteins of the Extracellular Matrix. *. Osteoadherin is a recently described bone proteoglycan containing keratan sulfate. It promotes integrin (α v β 3 )-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegård, D. (1998) J. Cell Osteoadherin (OSAD), a keratan sulphate PG is a member of the small leucine-rich (SLRP) family of PGs and unlike other SLRPs, OSAD expression is restricted to mineralized tissues. It is proposed to have a high affinity for hydroxyapatite and has been shown to be expressed by mature osteoblasts but its exact role remains to be elucidated. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). Leucine-rich repeat (LRR) motifs consist of approximately 20 - 30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta-sheet and one alpha-helix.
It had an apparent molecular mass of 85 kD under reducing conditions by SDS-PAGE. ELISA detected osteoadherin in bovine bone only, and immunohistochemical analysis of bovine fetal rib growth plate showed osteoadherin exclusively in primary bone spongiosa. Product Name: Human Osteoadherin ELISA Kit PicoKine™ See more Osteoadherin/OSAD/OMD products: Catalog# EK2017: Storage & Handling: Store at 4˚C for 6 months, at -20˚C for 12 months. The Human Osteoadherin IQELISA™ kit is an ultrasensitive ELISA utilizing qPCR detection for 10X more sensitivity with 10X less sample.
Bovine osteoadherin contains leucine-rich repeats (LRRs) and is also rich in aspartic acid and glutamic acid.
Leucine‐rich repeats (LRRs) with 20–30 amino acids in unit length are present in many proteins from prokaryotes to eukaryotes. The LRR‐containing proteins include a family of nine small proteoglycans, forming three distinct subfamilies: class I contains biglycan/PG‐I and decorin/PG‐II; class II: lumican, fibromodulin, PRELP, keratocan, and osteoadherin; and class III: epiphycan/PG The small leucine-rich repeat proteins (SLRPs), fibromodulin and osteoadherin, have N-terminal extensions with a variable number of O-sulfated tyrosine residues.
It promotes integrin (αvβ3)-mediated cell binding (Wendel, M., Sommarin, Y., … Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). LRR motifs consist of approximately 20‑30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta -sheet and one alpha -helix (1, 2). OMD (Osteomodulin) is a Protein Coding gene.
Among its related pathways are Diseases of glycosylation and HIV Life Cycle . An important paralog of this gene is KERA. T1 - Ultrastructural distribution of osteoadherin in rat bone shows a pattern similar to that of bone sialoprotein. AU - Ramstad, VE. AU - Franzén, Ahnders. AU - Heinegård, Dick. AU - Wendel, M. AU - Reinholt, FP. N1 - The information about affiliations in this record was updated in December 2015.
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In order to further assess this Recently, osteoadherin (OSAD) has been described as a new member of this family, that is expressed by mature bovine osteoblasts. Here, we report the Osteoadherin.
AU - Heinegård, Dick. AU - Wendel, M. AU - Reinholt, FP. N1 - The information about affiliations in this record was updated in December 2015. 1999-12-30 · Osteoadherin is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced.
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It promotes integrin (alphav beta3)-mediated cell binding (Wendel, M., Sommarin, Y., and Heinegârd, D. (1998) J. Cell Biol. 141, 839-847). The primary structure of bovine osteoadherin has now been determined by nucleo … 2019-10-18 · Osteoadherin (also termed osteomodulin) is encoded by the Omd gene and is a keratan sulfate proteoglycan of the class II subfamily of SLRPs. Osteoadherin is highly expressed in mineralized tissues, including bone and dentin; however, it's precise roles remain unknown. 1998-07-03 · Osteoadherin, a Cell-binding Keratan Sulfate Proteoglycan in Bone, Belongs to the Family of Leucine-rich Repeat Proteins of the Extracellular Matrix.